Background
Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder associated with systemic complications, including renal impairment resulting from intermittent hypoxia and sympathetic activity. This study aimed to evaluate renal dysfunction in cases with OSA, investigate its correlation with disease severity, and assess the impact of continuous positive airway pressure (CPAP) therapy on kidney function.
Methods
In this prospective cohort study, 100 participants (80 OSA cases and 20 healthy controls) were enrolled from Benha University Hospital (December 2022 and December 2024). All participants underwent comprehensive clinical evaluation, overnight polysomnography (PSG), renal function testing [serum creatinine, blood urea, estimated glomerular filtration rate (eGFR), urinary albumin-to-creatinine ratio (UACR)], and renal ultrasonography. OSA cases with moderate-to-severe …