The skin and joints may be affected by the chronic inflammatory illness known as
psoriasis. It may show up as different phenotypes. A systemic inflammatory disorder, it damages many
organs and tissues over time because to the persistent activation of the immune system and the
increased production of pro-inflammatory cytokines by immune-related cells. Rheumatological,
cardiovascular, and mental problems are among the many comorbidities linked to it. The role of genes
in the development of psoriasis should be carefully considered.