Background: Multiple Sclerosis is a long-term autoimmune, neurodegenerative and inflammatory condition that
impacts on the central nervous system. This study aimed to evaluate the effect of a health promotion self-care
program on knowledge, health promoting behaviors and quality of life for patients with multiple sclerosis. A quasi
experimental (pre/posttest) research design was utilized to conduct the study. Setting: The study was conducted at
Neurology Outpatient Clinic at Benha Health Insurance Hospital, Benha City, Egypt. Sampling: A simple random
sample was used to select 133 patients with multiple sclerosis. Three tools were used to collect data: I: Interviewing
questionnaire divided into three parts including the sociodemographic characteristics, health related data, and
patients’ knowledge regarding multiple sclerosis disease, II: The Health-Promoting Lifestyle Profile II (HPLP II),
and III: Hamburg Quality of Life Questionnaire for MS. Results showed that after applying the health promotion
self-care program, there was a significant difference in the mean scores of knowledge, health promoting behavior,
and quality of life of patients with MS (p