IoT is one of the most popular technologies in recent years due to the interconnection of various infrastructures, physical devices,
and software. To guarantee the security of Internet of Tings (IoT) pervasiveness, lightweight cryptographic solutions are needed
and this requires lightweight cryptographic primitives. Te choice of S-box in light block ciphers plays an important role in
characterizing the security-performance trade-of. Te choice of the 4 × 4 S-box for the lightweight constructions results in
compact hardware, speeding up the computational capability of the security algorithm unlike the 8 × 8 S-box. Tis work presents
efcient algebraic S-boxes for a fast image cryptosystem based on a strong nonlinear function which is expanded by a biological
technique depending on DNA. Te robustness of the proposed S-boxes is analysed and tested against various standard attack
criteria such as interpolation attacks, avalanche efect, and nonlinearity. Te great advantage of introducing S-boxes is that its
DSAC is the ideal value which is equal to zero. Also, other tests executed on these S-boxes guaranteed its robustness and excellent
security performance. Moreover, the experiments are applied with full description in two diferent modes; RGB and gray images.
Te results of all tests proved to have fast and strong efective S-boxes