Backdrop: A continuous care model is beneficial in enhancing healthy lifestyle and self-care practices for patients post total knee arthroplasty. Aim: This study was designed to evaluate the effect of the continuous care model on healthy lifestyle among patients post total knee arthroplasty. Research design: A quasi-experimental design was carried out in this research. Setting: This study was implemented at Orthopedic Outpatient Clinic at Benha Health Insurance Hospital and the studied patients` homes. Sample: A purposive sample of 64 patients post total knee arthroplasty was included in this study. Tools for data collection: Three tools were applied, I: A structured interview questionnaire which covered socio demographic characteristics of the patients, medical history, and knowledge regarding total knee arthroplasty, II: Healthy lifestyle post total knee arthroplasty and III: Quality of life scale of patients post total knee arthroplasty. Results: 20.3% of the studied patients had good knowledge level regarding total knee arthroplasty pre continuous care model implementation which raised to 76.6% post continuous care model implementation, 29.7% of the studied patients had satisfactory level regarding total healthy lifestyle post total knee arthroplasty pre continuous care model implementation which enhanced to 79.7% post continuous care model implementation, and 28.1% of the studied patients had good level of total quality of life post total knee arthroplasty pre continuous care model implementation which improved to 76.6% post continuous care model implementation. Conclusion: The continuous care model had a positive outcome in enhancing knowledge, promoting healthy lifestyle and quality of life of patients post total knee arthroplasty. Recommendations: Continuous care model needed to be incorporated into routine postoperative protocols for total knee arthroplasty patients to motivate long-lasting improvements in patients' lifestyle and quality of life.