Context: Hemodialys patients frequently experience the distressing side effects of restless legs syndrome and
intradialytic hypotension. It may induce patients to experience discomforting symptoms, lead to vascular access
thrombosis, and reduce the efficiency of dialysis. So, it is necessary to prevent this complication. Aim: The purpose
of this research was to evaluate effect of application of cool dialysate on controlling hypotension and restless leg
syndrome among patients undergoing hemodialysis. Methods: A purposive sample of 88 patients admitted to the
Hemodialys department at Benha University Hospital Qalyoubia, Egypt, was subjected to a quasi-experimental
research design (control group and study). Three tools were used, I: Structured Interviewing Questionnaires, II: and
intradialytic hypotension Assessment, and III: International restless legs syndrome Severity Rating Scale. Results
demonstrated that the incidence of intradialytic hypotension signs and symptoms after the second and fourth weeks
of intervention differed significantly between patients in study and control groups, with a statistically significant P
value of 0.003. Also, that there were high statistically significant differences between patients of both groups
regarding total level of restless legs syndrome post-intervention (2nd and 4th week), with a statistically significant
P-value of