Background: Colorectal cancer (CRC) ranks as the third most prevalent malignancy globally and represents a leading cause of cancer-related mortality worldwide. CXCL12, an essential chemokine, has been demonstrated to be critically involved in cancer metastasis. Aldolase A (ALDOA) is a crucial glycolytic enzyme that contributes to cellular energy production and has been implicated in tumor metabolism and tumor progression.
Objective: This study aimed to identify of CXCL12 and ALDOA immunohistochemical expression in CRC cases and correlation of their expression with clinicopathological data and patient’s survival of the studied cases to detect their potential prognostic role.
Material and methods: This retrospective study included 40 cases CRC immunohistochemically stained with CXCL12 & ALDOA and the results to be correlated with different clinicopathological variables and patient's survival.