Endometrial carcinoma is the most common invasive neoplasm of the female
reproductive tract. L1 cell adhesion molecule (L1CAM), Sperm-associated antigen
9 (SPAG9), and P53 have a role in the process of tumorigenesis and progression
of several human malignant tumors, however, the role of them in cancer of
endometrium is still not clear.
Aim
The study was performed to evaluate L1CAM, SPAG9, and P53 expression
about different clinicopathological parameters in endometrial endometrioid
adenocarcinoma.
Methods
The immunohistochemical study was performed on 50 cases of endometrial lesions
including endometrial hyperplasia without atypia (10 cases), endometrial hyperplasia
with atypia (10 cases), and endometrial endometrioid carcinoma (30 cases).
Immunohistochemical staining techniques were used to evaluate the role of L1CAM,
P53, and SPAG9 in endometrial endometrioid adenocarcinoma (EEC) and their relation
to different clinicopathological data and patient’s survival followed for 36 months.