Ebtehal Maher Abdel Aal El-sayed
Lecturer
Significance of expression of PD-L1, VEGF and CD8+ T cells in ovarian serous carcinoma: an Immunohistochemical study
Benha medical journal • 2023
Publication Information
Authors
Omneya Y. Bassyoni a , Ebtehal M. Abdel Aal a, Ahmed Khalil b
Keywords
PD-L1, VEGF and CD8+T cells.
Journal
Benha medical journal
Publisher
Not Available
Volume
40
Issue
3
Pages
745-758
publication.type
Local
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Background: Ovarian cancer is a lethal gynecological malignancy worldwide. The immune system plays a key role in preventing tumor development. Angiogenesis and immune evasion are vital for ovarian cancer progression and metastasis. Aim: This work aimed to evaluate the expression of PD-L1, VEGF and CD8 +T cells in ovarian serous carcinomas and correlate them with clinic-pathological variables. Material and methods: An Immunohistochemical study of PD-L1, VEGF and CD8+ T cells was performed on 50 cases of ovarian serous carcinomas. Results: PD-L1 & VEGF were over-expressed with statistical significance , in higher grade (P