Ebtehal Maher Abdel Aal El-sayed
Lecturer
Diagnostic Significance of Expression of IGF2, SMAD4, PTTG1 and Clinicopathological Parameters in Differentiating Adrenocortical Tumors
Benha medical journal • 2024
Publication Information
Authors
Omneya Y. Bassyoni, Ebtehal M. Abdel-Aal
Keywords
Adrenocortical adenoma, Adrenocortical carcinoma, IGF2, SMAD4, PTTG1.
Department of Pathology, Faculty of Medicine Benha University, Egypt. Corresponding to: Omneya Y. Bassyoni, Department of Pathology, Faculty of Medicine Benha University, Egypt. Email: omneyayoussef2015@gmail.com Received:15 April 2024 Accepted:4 June 2024 Print ISSN 1110-208X Online ISSN 2357-
Journal
Benha medical journal
Publisher
Not Available
Volume
41
Issue
5
Pages
372-385
publication.type
Local
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Among the most aggressive tumors is adrenocortical carcinoma. It is still a great challenge to distinguish between adrenocortical adenoma and carcinoma. For many tumors, IGF2 is essential to their growth and development. One of the genes that suppresses tumor growth is SMAD4 and one that may encourage tumorigenesis is PTTG1. Aim of this work: Evaluation of the clinicopathological factors, IGF2, SMAD4, and PTTG1 immuno-expression to distinguish adrenocortical tumors and, consequently, the therapeutic modalities. Material and Methods: A retrospective study was conducted on selected 40 cases of adrenocortical tumors on which immunohistochemical expression of PTTG1, SMAD4, and IGF2- were performed . Receiver operating characteristic (ROC) curves were performed to assess the diagnostic performance of the studied markers as well as clinicopathological variables in discriminating ACA from ACC. Results: Significant differences in tumor size, weight and high Weiss score- were important in differentiating ACA from ACC (p