Context: Infusion pump is an external medical device used to deliver fluids in controlled manner into the patient’s body for variety of environments and variety of purposes. Aim: the study aim is to evaluate effect of training program on critical care nurses performance regarding infusion pump medications administration. Methods: The study used a quasi-experimental design, specifically employing a pre/post-test methodology on a convenience sample of (70) nurses who assigned to care of critical patient who receive medications via infusion pump. This study was conducted in ICU at Benda University Hospital. The study utilized the following tools: I) Self-administered questionnaire to evaluate nurses knowledge regarding infusion pump medications administration. II) Observational checklist to evaluate nurses' actual practices regarding preparing phase, setting up phase, administration phase and post administration phase of infusion pump medications administration. Results: 20.0 % of studied nurses had satisfactory level of total knowledge about infusion pump medications administration pre training program implementation to be significantly improved during immediate and post one month of training program implementation among 71.4% & 65.7%, respectively. While 21.4 % of studied nurses had a competent level of total practice pre program implementation to be significantly improved during immediate and post three months of program implementation among 80.0% &71.4%, respectively. There was highly significant difference in total nurses’ knowledge and practice score within study periods observed as p