Background: Deficiency of vitamin D has become a global
public health problem, with nearly 1 billion people worldwide
being in a state of vitamin D insufficiency or deficiency. The aim
of this work was to evaluate the role of hypovitaminosis D in
diabetes- related anemia of chronic disease and value of its
replacement in response to therapy. Methods: This randomized
control trial included patients with diabetes- related anemia of
chronic disease), the least number is 318 patients. The three
groups were randomized equally; group 1 was with diabetesrelated anemia of chronic disease) with normal 25 hydroxy
vitamin D and received treatment for anemia, group 2 was with
diabetes- related anemia of chronic disease with low level of 25
hydroxy vitamin D, and group 3 was with diabetes, but no
anemia then follows up for hemoglobin concentration. Those
Patients were informed about using vitamin D in treatment
(benefits and side effects) in addition to treatment of specific
anemia, then we assessed anemia after three months. Results:
The study found no significant difference in age, sex, or type of
diabetes mellitus (DM) between groups. However, individuals
with anemia, particularly those with low vitamin D levels, had
lower serum iron and TIBC levels and higher ferritin levels.
Vitamin D levels were negatively correlated with ferritin and
positively correlated with iron and TIBC. HbA1C levels had
negative correlations with iron, TIBC, and WBCs. Conclusion:
The current study suggested that there was close relationship
between vitamin D deficiency and anemia in diabetic patients.