Sara Metwally Abdallah Mohamed Abdelsayed
Lecturer
Revolutionizing cancer treatment with Halomonas Aquamarina L-Glutaminase: insights from in vitro and computational studies
Scientific Reports (Nature Portfolio) • 2025
Publication Information
Authors
S Abdelsayed; A Elmetwalli; J Hassan; M O Abdel Monem; A H El-Far; F Ameen; M G Hassan
Keywords
Halomonas aquamarina; L-glutaminase; cancer therapy; metabolism; marine biotechnology
Journal
Scientific Reports (Nature Portfolio)
Publisher
Springer Nature (Scientific Reports)
Volume
15
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
This study explores the potential of Halomonas aquamarina–derived L-glutaminase (L-GLS) as a novel anticancer agent by combining in vitro enzymatic assays and computational analyses. L-GLS was isolated and purified from marine bacterial strains, achieving high specific enzymatic activity and demonstrating optimized functional parameters in terms of pH and temperature. Computational studies support the enzyme’s interaction with cancer-related metabolic pathways, highlighting its promise as a therapeutic strategy by targeting glutamine metabolism in tumor cells.
Nature
Nature