Knee replacement (KR) surgery, also known as knee arthroplasty (KA),
remains the surgical gold standard treatment for patients suffering from osteoarthritis (OA) to
restore the quality of life in patient with knee osteoarthritis. The aim of the study: This study
aimed to evaluate the effect of evidence-based nursing guidelines on patients' quality of life after
knee replacement surgery. Research design: Quasi experimental research design (pre/post) was
used to conduct the aim of this study. Setting: The study was conducted in orthopedic department
affiliated to surgical department at Benha University Hospital, Qualyubia Governorate, Egypt.
Subjects: A Convenience sample of all available adult (100) patients undergoing knee replacement
surgery. Tools: Two tools were used; (1) Patients' structured interviewing questionnaire, it involved
the patients' socio-demographic characteristics, medical history and patients' knowledge assessment
including (knee joint, KR surgery and health practices regarding well balanced diet, exercises and
physical activity, treatment and follow-up post KR surgery. (2) Patients’ Quality of life Scale, it
involved three domains physical, psychological and social domains. Results: The result of this
study revealed that, the total mean score of patients' knowledge regarding knee replacement surgery
was (21.18 ± 3.47) at pre guidelines implementation which changed to (34.74 ± 1.61) during
immediate post, (33.36 ± 1.82) post 3 months and slightly declined to ( 31.03 ± 2.39) post 6 months
period of guidelines implementation, with high significant differences (p=