Ahmed Mohamed Hamed Mahmod
Professor
Efficacy and safety of Nd:YAG laser alone compared with combined Nd:YAG laser with intralesional steroid or botulinum toxin A in the treatment of hypertrophic scars
• 2020
Publication Information
Authors
Sherine Hosny Abdel Rahman & Manal Saied Mohamed & Ahmed Mohamed Hamed
Keywords
Not Available
Journal
Not Available
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Abstract
The aimof this study is to evaluate the efficacy and safety of Nd:YAG laser alone or in combination with intralesional injection of
botulinum toxin type A or intralesional injection of steroid in treatment of hypertrophic scars. This study included 45 patients
with hypertrophic scars who were randomly divided into three equal groups. All participants received 4 sessions of Nd:YAG
laser at 4-week intervals. Immediately after the laser treatment, patients in group II were assigned to intralesional triamcinolone
acetonide, and those in group III were assigned to intralesional botulinumtoxin type A. All patients were followed up monthly for
3 months after the last session for any recurrence, or side effects. Clinical evaluation of the cases was done by Vancouver Scar
Scale. Hypertrophic scars in the three groups showed a significant improvement (p < 0.001) comparedwith before treatment in all
variables (except for pigmentation) and also a significant improvement in pruritus, pain, and patient relief. The highest percentage
of improvements was seen in patients treated with Nd:YAG laser combined with intralesional steroid in all variables according to
Vancouver Scar Scale. The degree of improvement was negatively correlated with the patients’ age. The three treatment
modalities were effective, safe with minimal side effects. Nd:YAG laser followed by intralesional injection of Triamcinolone
acetonide had the highest percentage of Vancouver Scar Scale reduction. Combination therapy of Nd:YAG laser with
intralesional injection of either Triamcinolone acetonide or Botox revealed better results than using Nd:YAG as a single
therapeutic modality for HTS.
The aimof this study is to evaluate the efficacy and safety of Nd:YAG laser alone or in combination with intralesional injection of
botulinum toxin type A or intralesional injection of steroid in treatment of hypertrophic scars. This study included 45 patients
with hypertrophic scars who were randomly divided into three equal groups. All participants received 4 sessions of Nd:YAG
laser at 4-week intervals. Immediately after the laser treatment, patients in group II were assigned to intralesional triamcinolone
acetonide, and those in group III were assigned to intralesional botulinumtoxin type A. All patients were followed up monthly for
3 months after the last session for any recurrence, or side effects. Clinical evaluation of the cases was done by Vancouver Scar
Scale. Hypertrophic scars in the three groups showed a significant improvement (p < 0.001) comparedwith before treatment in all
variables (except for pigmentation) and also a significant improvement in pruritus, pain, and patient relief. The highest percentage
of improvements was seen in patients treated with Nd:YAG laser combined with intralesional steroid in all variables according to
Vancouver Scar Scale. The degree of improvement was negatively correlated with the patients’ age. The three treatment
modalities were effective, safe with minimal side effects. Nd:YAG laser followed by intralesional injection of Triamcinolone
acetonide had the highest percentage of Vancouver Scar Scale reduction. Combination therapy of Nd:YAG laser with
intralesional injection of either Triamcinolone acetonide or Botox revealed better results than using Nd:YAG as a single
therapeutic modality for HTS.