Ahmed kamal Eldein Abbass
Lecturer
Progestin-Primed Ovarian Stimulation (PPOS) Versus Flexible GnRH Antagonist Protocol (FGnRHan) In Women with Polycystic Ovary Syndrome (PCOS): A Retrospective Analysis of Clinical Outcomes and Ovarian Response of a Substantial Cohort
Benha Medical Journal • 2024
Publication Information
Authors
Fatma Faisal Ibrahim Darwish1; Ashraf nassif Elmantwe* 2; Hossam Elbanhawy3; Ahmed Kamal Eldin Abbas4; Mohamed Anwar El noury5; ahmed mousad baioumy Ahmed6
Keywords
GnRHan protocol.progestin
Journal
Benha Medical Journal
Publisher
10.21608/bmfj.2023.253331.1970
Volume
41
Issue
1
Pages
1-6
publication.type
Local
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Background: Ovarian Stimulation Response (OSR) in polycystic ovarian syndrome (PCOS) ladies is a controversial issue
Aim: to evaluate outcomes of Fixed Progestin-Primed Ovarian Stimulation (FPPOS) and Flexible GnRH Antagonist Protocol (FGnRHan) on OSR and pregnancy outcomes in PCOS ladies undergoing intracytoplasmic sperm injection-frozen embryo transfer (ICSI-FET).
Patients and Methods: A retrospective assessment of PCOS ladies undergoing ICSI-FET cycles at Riyadh Fertility Center, Agouza, Giza Governorate (RFC), and Benha University Hospital (BUH), over the last 5 years. The outcomes were the frequencies of clinical pregnancy, continued pregnancy, live births, fertilization, early LH surge, and other OSR results.
Results: of 950 ladies included, 420 had FPPOS (study group) and 390 (control group) had the GnRHan protocol. Both groups' baseline metrics showed similarities. Mature and fertilized oocytes showed no discernible difference between the two groups (P > 0.5). Premature luteinization was rare in both groups, and there was no statistically significant difference (P > 0.5). Additionally, there was no discernible difference in the clinical pregnancy rate per frozen embryo transfer cycle (FETC) between the FGnRHan and FPPOS groups (P > 0.5). Also, continuing pregnancy rates, miscarriage rates, biochemical pregnancy rates, and implantation rates, showed statistical similarities across the groups (P > 0.05). However, there was a considerable decrease in cost calculated in local currency (5.8±3.1 vs. 8.8±4.1, p =0.001) between the FPPOS and FGnRHan groups.
Conclusion: in PCOS ladies who had ICSI-FET, the FPPOS protocol proves to be a powerful, practical, user-friendly, economical, and clinically equivalent alternative to the standard FGnRHan protocol.
Aim: to evaluate outcomes of Fixed Progestin-Primed Ovarian Stimulation (FPPOS) and Flexible GnRH Antagonist Protocol (FGnRHan) on OSR and pregnancy outcomes in PCOS ladies undergoing intracytoplasmic sperm injection-frozen embryo transfer (ICSI-FET).
Patients and Methods: A retrospective assessment of PCOS ladies undergoing ICSI-FET cycles at Riyadh Fertility Center, Agouza, Giza Governorate (RFC), and Benha University Hospital (BUH), over the last 5 years. The outcomes were the frequencies of clinical pregnancy, continued pregnancy, live births, fertilization, early LH surge, and other OSR results.
Results: of 950 ladies included, 420 had FPPOS (study group) and 390 (control group) had the GnRHan protocol. Both groups' baseline metrics showed similarities. Mature and fertilized oocytes showed no discernible difference between the two groups (P > 0.5). Premature luteinization was rare in both groups, and there was no statistically significant difference (P > 0.5). Additionally, there was no discernible difference in the clinical pregnancy rate per frozen embryo transfer cycle (FETC) between the FGnRHan and FPPOS groups (P > 0.5). Also, continuing pregnancy rates, miscarriage rates, biochemical pregnancy rates, and implantation rates, showed statistical similarities across the groups (P > 0.05). However, there was a considerable decrease in cost calculated in local currency (5.8±3.1 vs. 8.8±4.1, p =0.001) between the FPPOS and FGnRHan groups.
Conclusion: in PCOS ladies who had ICSI-FET, the FPPOS protocol proves to be a powerful, practical, user-friendly, economical, and clinically equivalent alternative to the standard FGnRHan protocol.