Objective: Despite reduced systemic toxicity compared to other medicines, hydroxychloroquine is a widely usedimmunosuppressive agent for the treatment of different autoimmune disorders. It may induce serious retinalimpairment and blindness. The purpose of this research is to evaluate the early OCT results in preclinical retinopathyof hydroxychloroquine (HCQ). Patients and procedures: This cross-sectional comparative study has taken place inophthalmology and rheumatology clinics in Benha university hospitals; twenty eyes of rheumatic HCQ patients forover two years and 20 eyes of ordinary gender patients have been examined and imaged fully with spectrum opticcoherence tomography (SD-OCT). The whole research group had a normal look of a fundus. Results: For more thantwo years of usage with still normal fundus, external retinal dilation as central foveal and parafoveal dilution wasobserved with SD-OCT in individuals with chronic HCQ. In just 2 rheumatic individuals the IS/OS junction wasdisrupted (10 percent ). Only three rheumatic patients suffered from colour vision (15 percent ). Conclusion:Preclinical HCQ retinopathy may be detected in the screening of SD-OCT rheumatic patients, particularly with theincreasing availability of SD-OCT machinery in most visual centres.

(PDF) Evaluation of Hydroxychloroquine Effect on the Retinal Layers by Spectral-Domain Optical Coherence Tomography. Available from: https://www.researchgate.net/publication/355529791_Evaluation_of_Hydroxychloroquine_Effect_on_the_Retinal_Layers_by_Spectral-Domain_Optical_Coherence_Tomography [accessed Jul 18 2024].