Background: Nasal septal deviation disrupts nasal functioning mainly by obstruction, but it also impairs mucociliary clearance by increasing mucus secretion, compromising normal ciliary movements, and causing airway epithelium damage. This study aimed to study the effect of hyaluronic acid in accelerating nasal mucosa recovery after septplasty. Methods: This comparative interventional study included 40 subjects who underwent septoplasty. The patients were assigned into two equal groups: Control group: Each patient was subjected to alkaline nasal wash after septoplasty 3 times per day for 15 days. Study group: Each patient was subjected to sodium hyaluronate spray after septoplasty 3 times per day for 15 days. Results: Study cases had significantly lower saccharin test results at day 15 (p < 0.001) and day 30 (p=0.04). According to postoperative endoscopic examination findings at day 15, a significant higher distribution of all postoperative endoscopic examination findings in control group compared to study group (p < 0.05 in all findings). Conclusion: Sodium hyaluronate spray showed promising results in enhancing nasal mucosa recovery post-septoplasty. Its use led to improved saccharin test outcomes and reduced postoperative endoscopic findings compared to alkaline nasal wash.