Alaa El-Sayed Ahmed Ahmed Amin
Prof. Emeritus
New colorimetric methods for the determination of indapamide and its formulations.
• 2001
Publication Information
Authors
H.M. Saleh, A.S. Amin and M. El-Mammli
Keywords
Not Available
Journal
Not Available
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Two simple and sensitive methods for the determination of indapamide in pure and in dosage forms are developed. These methods are based on the oxidation of indapamide with iron(III) in acidic medium. The liberated iron(II) reacts with 1,10-phenanthroline (Method A) and the ferroin complex is colorimetrically measured at λmax 509 nm against reagent blank. Method B is based on the reduction of Fe(III) by the drug. Iron(II) forms a colored complex (λmax 522 nm) with 2,2′-bipyridyl. Optimization of the experimental conditions is described. Beer’s law is obeyed in the concentration range 1.0–12 µg ml−1 and 4.0–18 µ g ml−1 for A and B, respectively. The apparent molar absorptivity and Sandell sensitivity for method A is 3 × 104 L mol−1 cm−1 and 0.0188 µ g cm−2, while for method B is 2.3 × 104 L mol−1 cm−1 and 0.0159 µg cm−2. The detection and quantification limits are calculated. The developed methods are applied successfully for the determination of indapamide in pure and in tablet form without interference from common excepients.
