Amany Ibrahim Mustafa
Professor
Cross talk between oxidative stress and inflammation in alopecia areata
journalof cosmetic dermatology • 2021
Publication Information
Authors
Amany Ibrahim Mustafa 1, Rana Atef Khashaba 2, Eman Fawzy 3, Shimaa Mohamad AbdElRahman Baghdady 4, Shymaa Mostafa Rezk 1
Keywords
Not Available
Journal
journalof cosmetic dermatology
Publisher
Wiley
Volume
20
Issue
7
Pages
Not Available
publication.type
International
Paper Link
Open Link
Supplementary Materials
Amany Ibrahim Mustafa_J of Cosmetic Dermatology - 2020 - Mustafa - Cross talk between oxidative stress and inflammation in alopecia areata (4).pdf
Abstract
Abstract
Background: Although the etiopathogenesis of alopecia areata (AA) is still unclear, inflammation, oxidative stress, and subsequent DNA damage might be considered role players in disease development.
Aim: We aimed at exploring the potential link between oxidative DNA damage and inflammation in AA patients through measuring 8-hydroxy deoxyguanosine (8-OHdG), high mobility group box 1 protein (HMGB1), and one of the inflammatory mediators, C-reactive protein (CRP).
Methods: A total of 79 subjects (49 AA patients in addition to 30 apparently healthy control subjects) were tested for serum levels of 8-OHdG, HMBG1, and CRP.
Results: Compared with the control group, serum 8-OHdG, HMBG1, and CRP levels were significantly elevated in the studied patients group (0.031,
Background: Although the etiopathogenesis of alopecia areata (AA) is still unclear, inflammation, oxidative stress, and subsequent DNA damage might be considered role players in disease development.
Aim: We aimed at exploring the potential link between oxidative DNA damage and inflammation in AA patients through measuring 8-hydroxy deoxyguanosine (8-OHdG), high mobility group box 1 protein (HMGB1), and one of the inflammatory mediators, C-reactive protein (CRP).
Methods: A total of 79 subjects (49 AA patients in addition to 30 apparently healthy control subjects) were tested for serum levels of 8-OHdG, HMBG1, and CRP.
Results: Compared with the control group, serum 8-OHdG, HMBG1, and CRP levels were significantly elevated in the studied patients group (0.031,