Amira Elsayed Abd Elkhalek Soliman Eid
Asst. Professor
Evaluation of the significance of human class I homeobox A13 and STK4/MST1 expression in conventional colorectal adenoma and adenocarcinoma and correlation with clinicopathological parameters (immunohistochemical study)
Egyptian Journal of Pathology • 2023
Publication Information
Authors
Ebtehal M. Abdel-Aal, Amira El-Sayed Soliman
Keywords
-colorectal adenocarcinoma, human class I homeobox A13, STK4/MST1
Journal
Egyptian Journal of Pathology
Publisher
Wolters Kluwer - Medknow
Volume
42
Issue
Not Available
Pages
102-111
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Background
Colorectal carcinoma (CRC) is the third most common cancer in the world. Human
class I homeobox A13 (HOXA13) was initially identified as a transcription factor and
has an important role in embryonic development and malignant transformation.
Mammalian STE20-like kinase 1 (STK4/MST1) encodes a serine/threonine kinase
that is the mammalian homolog of the Hippo pathway and plays an important role
in controlling cell growth, apoptosis, and organ size.
Aim
This work aimed to evaluate the role of HOXA13 and STK4/MST1 in conventional
colorectal adenoma and adenocarcinoma.
Materials and methods
This retrospective study was carried out on 20 cases of conventional colorectal
adenoma and 30 cases of conventional colorectal adenocarcinoma. HOXA13 and
STK4/MST1 immunostaining was done and assessed for each case. Correlation
with the clinicopathological findings and statistical analysis was studied.
Results
In the carcinoma cases, there was a highly significant direct statistical
correlation between HOXA13 expression and tumor grade, lymph node
metastasis, and TNM stage (P
Colorectal carcinoma (CRC) is the third most common cancer in the world. Human
class I homeobox A13 (HOXA13) was initially identified as a transcription factor and
has an important role in embryonic development and malignant transformation.
Mammalian STE20-like kinase 1 (STK4/MST1) encodes a serine/threonine kinase
that is the mammalian homolog of the Hippo pathway and plays an important role
in controlling cell growth, apoptosis, and organ size.
Aim
This work aimed to evaluate the role of HOXA13 and STK4/MST1 in conventional
colorectal adenoma and adenocarcinoma.
Materials and methods
This retrospective study was carried out on 20 cases of conventional colorectal
adenoma and 30 cases of conventional colorectal adenocarcinoma. HOXA13 and
STK4/MST1 immunostaining was done and assessed for each case. Correlation
with the clinicopathological findings and statistical analysis was studied.
Results
In the carcinoma cases, there was a highly significant direct statistical
correlation between HOXA13 expression and tumor grade, lymph node
metastasis, and TNM stage (P