Amira Elsayed Abd Elkhalek Soliman Eid
Asst. Professor
Significance of Expression of VEGF, BCL-2, p63 and β‑hCG in Gestational Trophoblastic Diseases
Benha medical journal • 2025
Publication Information
Authors
Omneya Y. Bassyonia, Amira E. Solimana, Labiba K. El Sayedb, Rania G. Roshdy
Keywords
GTD, Choriocarcinomas, Partial mole, VEGF,
β‑hCG
Journal
Benha medical journal
Publisher
Medknow
Volume
42
Issue
4
Pages
594-593
publication.type
Local
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Background: A diverse range of conditions linked to an
abnormal trophoblast growth are collectively known as
gestational trophoblastic disease (GTD), which are classified
into: tumor-like lesions, molar pregnancies and gestational
trophoblastic neoplasms. Aim of the work: to study
Immunohistochemical expression of VEGF, BCL-2, p63 and
serum β‑hCG in hydropic abortion, molar pregnancy &
choriocarcinoma to elucidate their role in pathogenesis and
diagnosis in these entities. Material and Methods: This
retrospective Immunohistochemical study of VEGF, BCL-2, p63
& serum β‑hCG- was carried upon 65 selected cases of
gestational trophoblastic diseases. Results: VEGF was increased
gradually from hydropic abortion, molar pregnancy to
choriocarcinoma (P=0.000). While BCL-2 and p63 were
downregulated markedly from hydropic abortion to be weakly
or negatively expressed for choriocarcinoma cases (p=0.000).
Serum β‑hCG also increased in the same pattern as VEGF (P
=0.000). BCL-2 & p63 and β‑hCG are more sensitive (100% &
90% & 100%) and specific (56.4%, 100%, 99%, respectively) in
diagnosis of choriocarcinoma. BCL-2 & p63- were highly
sensitive markers (81.8% & 100%) in differentiating hydropic
abortion from molar pregnancy. Conclusion: VEGF, BCL-2, p63
expression and elevated serum β‑hCG level might have role in
gestational trophoblastic disease pathogenesis and progression.
Combined expression of BCl-2, p63 and high β‑hCG, might be
useful to differentiate choriocarcinoma from other gestational
trophoblastic diseases and hence target therapy. BCl-2, p63 could
be used as markers for early diagnosis of molar pregnancy.
abnormal trophoblast growth are collectively known as
gestational trophoblastic disease (GTD), which are classified
into: tumor-like lesions, molar pregnancies and gestational
trophoblastic neoplasms. Aim of the work: to study
Immunohistochemical expression of VEGF, BCL-2, p63 and
serum β‑hCG in hydropic abortion, molar pregnancy &
choriocarcinoma to elucidate their role in pathogenesis and
diagnosis in these entities. Material and Methods: This
retrospective Immunohistochemical study of VEGF, BCL-2, p63
& serum β‑hCG- was carried upon 65 selected cases of
gestational trophoblastic diseases. Results: VEGF was increased
gradually from hydropic abortion, molar pregnancy to
choriocarcinoma (P=0.000). While BCL-2 and p63 were
downregulated markedly from hydropic abortion to be weakly
or negatively expressed for choriocarcinoma cases (p=0.000).
Serum β‑hCG also increased in the same pattern as VEGF (P
=0.000). BCL-2 & p63 and β‑hCG are more sensitive (100% &
90% & 100%) and specific (56.4%, 100%, 99%, respectively) in
diagnosis of choriocarcinoma. BCL-2 & p63- were highly
sensitive markers (81.8% & 100%) in differentiating hydropic
abortion from molar pregnancy. Conclusion: VEGF, BCL-2, p63
expression and elevated serum β‑hCG level might have role in
gestational trophoblastic disease pathogenesis and progression.
Combined expression of BCl-2, p63 and high β‑hCG, might be
useful to differentiate choriocarcinoma from other gestational
trophoblastic diseases and hence target therapy. BCl-2, p63 could
be used as markers for early diagnosis of molar pregnancy.