Background: Sonographic assessment of fetal growth for the estimation of fetal weight is a common practice in obstetrics, providing valuable information for planning the mode of delivery and management of labor. The aim of this study was to assess the role of fetal mid- thigh soft tissue thickness (MTSTT) in predicting fetal weight. Methods: This prospective observational study was conducted on 138 singleton pregnant women aged from 20 to 35 years admitted to the obstetric ward with gestational age from 37 to 40 weeks and normal amniotic fluid and planned for delivery within 48 hours. The ultrasound (US) parameters including bi-parietal diameter (BPD), head circumference (HC) abdominal circumference (AC), femur length (FL) and MTSTT were measured respectively. The estimated fetal weight (EFW) was assessed according to Scioscia's, Vintzileos’, and Hadlock's formulae. Results: There was a significant strong positive correlation between ABW and both Scioscia's formula (r 0.787, P value