Background: E learning is a formalized teaching with the aid of electronic resources wherein education can be deliveredto large number of students (the target audience) at same or different time. The synchronized e-learning was the panaceaat the time of the covid- 19 pandemic. However, it negatively influenced the learners’ performance, attitude andlearningoutcomes. Aim: To assess the effect of obstacles faced nursing students related applying e-learning during COVID-19pandemic on their attitudes. A descriptive correlational study design was used. The research was carried out at BenhaUniversity's Faculty of Nursing in Egypt. Subjects: During the academic year 2020/2021, a stratified randomsamplingtechnique was used to choose 25% of students from each of the four academic years enrolled in the Faculty of NursingatBenha University. Tools: Interviewing questionnaire, attitude towards e-learning scale, and obstacles of e-learningquestionnaires. Results: 55.5 % of students expressed negative attitudes regarding e-learning, according to the findings. The highest level of total obstacles presented among academic students in the first year (66.8%) and the lowest level oftotal obstacles presented among academic students in the fourth year (57%) were encountered by nursing students whenusing e-learning. The most common dimensions of obstacles to e-learning were infrastructure and technologicaladvancements, technical and managerial assistance and instructors' characteristics (88.2%, 86.3%and 83.3%respectively). Conclusions: There was a highly statistically significant negative correlation between obstacles facing nursingstudentsand their attitudes towards e-learning. Recommendations: In light of the uniqueness of learning programs, thestudyproposes that higher education institutions improve their e-learning strategy in order to encourage students' academicachievement.