Background: The flipped classroom is an instructional approach that emphasizes students' active learning while reconstructing traditional teaching techniques. Aim: This research aimed to evaluate the effect of flipped classroom strategy versus conventional teaching methods on academic achievement, self-confidence and perception of nursing students Design: A quasi-experimental research design (two groups "control & study", ″Posttest only″) Setting: The present research conducted at obstetrics and gynecological nursing department in faculty of nursing, Benha University in the first semester of the 2023–2024 academic year. Sample: A purposive sample of 345 third year nursing Tools: Five tools were used: A structured self-administered questionnaire, nursing students' perception of learning strategy scale, self-confidence in learning scale, students' opinions scale and students' challenges questionnaire. Results: The mean scores regarding academic achievement, self-confidence and perception showed highly statistically significant difference between flipped classroom and conventional teaching groups post-implementation with (p- value