Background: Behcet's disease (BD) is an autoimmune systemic vasculitis with an unknown origin. Recent
discoveries have proven the essential role of Serum Amyloid A (SAA) in the pathophysiology of inflammatory
rheumatic illnesses, including its involvement in the activation of the inflammasome cascade and the recruitment of
interleukin 17-producing T helper cells.
Aim of the work: This study aimed to measure the level of SAA in Behçet’s disease and to examine the relation of
SAA levels with disease activity and different organ involvement.
Patients and Methods: This case-control research was done on 30 Behcets' cases which were subjected to history
taking, full clinical examination, and assessment of disease activity by Behcet Disease Current Activity Form
(BDCAF). Investigation in the form of CBC, ESR, CRP, and SAA were assessed.
Results: Serum amyloid-A level was significantly greater in BD cases when contrasted to controls (P