Background: Total knee arthroplasty “TKA” is described among the most commonly performed surgical interventions in orthopedics worldwide. Post TKA, bio-psychosocial needs is considered a vital aspect of care as patients may experience intense disabling pain and psychosocial problems that may negatively influence recovery and outcomes Aim: To evaluate the effect of bio-psychosocial health model based educational program on patients' needs post total knee arthroplasty. Design: A quasi experimental (pre/posttest) research design was used to achieve the aim of this study. Setting: Orthopedics inpatient and outpatient departments at Benha University Hospital. Sample: A purposive sample of 66 adult patients. Tools: Tool I: Patients' interview questionnaire, it includes two parts; 1) socio-demographic characteristics of the studied patients, 2) patients’ clinical data. Tool II: Postoperative bio-psychosocial needs assessment; it included three parts; (a)-WOMAC Index, (b)-Hospital Anxiety and Depression Scale, (c)-Social Dysfunction Rating Scale. Results: A statistical significant improvement was found between pre-educational program application and after as well follow up post educational program application regarding patient’s total knowledge level. Also, a statistical significant difference between pre- educational program application and after as well follow up post educational program application among the studied patients regarding all domains of physical, psychological and social needs at P-value ≤ 0.05. Conclusion: Application of a bio-psychosocial health model based educational program had a significant statistically improvement effect on patients knowledge and their bio-psychosocial needs. Recommendations: Similar studies are needed to assess the long-term effects of such health education models.