Ibrahim Zaghloul Abdelbaky
Asst. Professor
Hybrid transformer-CNN model for accurate prediction of peptide hemolytic potential
Scientific Reports • 2024
Publication Information
Authors
Sultan Almotairi, Elsayed Badr, Ibrahim Abdelbaky, Mohamed Elhakeem, Mustafa Abdul Salam
Keywords
Not Available
Journal
Scientific Reports
Publisher
Nature Publishing Group UK
Volume
14
Issue
1
Pages
14263
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Hemolysis is a crucial factor in various biomedical and pharmaceutical contexts, driving our interest in developing advanced computational techniques for precise prediction. Our proposed approach takes advantage of the unique capabilities of convolutional neural networks (CNNs) and transformers to detect complex patterns inherent in the data. The integration of CNN and transformers' attention mechanisms allows for the extraction of relevant information, leading to accurate predictions of hemolytic potential. The proposed method was trained on three distinct data sets of peptide sequences known as recurrent neural network-hemolytic (RNN-Hem), Hlppredfuse, and Combined. Our computational results demonstrated the superior efficacy of our models compared to existing methods. The proposed approach demonstrated impressive Matthews correlation coefficients of 0.5962, 0.9111, and 0.7788 respectively
