Background: Entrepreneurial orientation and organizational culture are the most common
tactics for effectiveness in the current competitive environment. The research aimed to assess
entrepreneurial orientation and organizational culture among head nurses and its relations to
organizational effectiveness. Research design: Descriptive correlational design was applied.
Setting: The study was conducted in all medical and surgical units (57) in Benha University
Hospital. Sampling: All available head nurses and their assistants (86) working in the
previously mentioned setting. Instruments: Four sections were used for data collection;
Personal data of the participants, Entrepreneurial Orientation Scale, Organizational Culture
Assessment Instrument & Organizational Effectiveness Scale. Results: Revealed that more
than half (52.3% and 58.1%) of the studied head nurses had a high entrepreneurial orientation
and positive perception of organizational culture, respectively. Also, nearly half (48.8%) had
a high perception of organizational effectiveness in the studied setting. Conclusion: There was
a highly statistically significant positive correlation between head nurses' perception of
entrepreneurial orientation and organizational culture, with organizational effectiveness at (P
value < 0.01). The study recommended: Supporting the head nurses' autonomy, job flexibility,
and security by providing organizational culture contributes to the explosion of energies and
the generation of ideas that lead to organizational effectiveness.