Frahat Foda Ali Foda
Prof. Emeritus
Attenuation of Some Metabolic Deterioration Induced by Diabetes Mellitus Using Different Jatropha curcas Extracts
Int. J. Pharm. Sci. Rev. Res • 2015
Publication Information
Authors
Frahat F Ali, Farouk K. El-Baz, Ahmed A Abd El-Rahman, Hanan F. Aly, Amal A Mohamed, Safaa A Saad
Keywords
Diabetes mellitus, Glibenclamide, J. curcas, STZ.
Journal
Int. J. Pharm. Sci. Rev. Res
Publisher
Not Available
Volume
30
Issue
2
Pages
164-171
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
The present research focuses on pharmacological effects of Jatropha curcas extracts on specific biochemical parameters in
streptozotocin (STZ)-induced diabetic rats as compared to glibenclamide antidiabetic drug. Diabetes mellitus (DM) was induced
using STZ (45 mg/kg b.w). J. curcas extracts were orally administered at a dose of 250 mg/kg/day and glibenclamide at a dose of
10 mg/kg/day for 30 days. Creatinine, urea, inflammatory biomarkers; C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α)
and interlukin-10 (IL-10) levels were measured in rats blood serum. Creatinine, urea, CRP and TNF-α levels were significantly
increased in diabetic rats with percentages of 100, 53.33, 136.45 and 78.45%, respectively. However, IL-10 level showed significant
decrease with percentage 39.36%. The results showed that all J. curcas extracts have a positive effect against creatinine, urea, CRP
and TNF-α high level besides, relieving kidney disorders associated with DM. J. curcas could be applied effectively to reduce renal complications paralleling to DM.
streptozotocin (STZ)-induced diabetic rats as compared to glibenclamide antidiabetic drug. Diabetes mellitus (DM) was induced
using STZ (45 mg/kg b.w). J. curcas extracts were orally administered at a dose of 250 mg/kg/day and glibenclamide at a dose of
10 mg/kg/day for 30 days. Creatinine, urea, inflammatory biomarkers; C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α)
and interlukin-10 (IL-10) levels were measured in rats blood serum. Creatinine, urea, CRP and TNF-α levels were significantly
increased in diabetic rats with percentages of 100, 53.33, 136.45 and 78.45%, respectively. However, IL-10 level showed significant
decrease with percentage 39.36%. The results showed that all J. curcas extracts have a positive effect against creatinine, urea, CRP
and TNF-α high level besides, relieving kidney disorders associated with DM. J. curcas could be applied effectively to reduce renal complications paralleling to DM.