Nematicides are used in controlling plant parasitic nematode for many years. The harmful effect of nematicides was threaten the environment so that there was a high need to find alternatives. Furfural derivatives are one of the promising alternatives to fill this need. In this study 6 furfural derivatives were Synthesised and applied against Meloidogyne incognita and Tylenchulus semipenetran . In vitro tests showed gradual mortality rates in the second stage juvenile (J2) of M. incognita and T.semipenetran when immersed in concentrations of furfural derivatives. These results indicated that furfural derivatives can affect juvenile viability of M. incognita and T. semipenetran . Furfural derivatives may therefore be one of the considerable potentials as an appropriate alternative for class I nematicides. Furfural derivatives were toxic to both tested nematode species. The toxic effect was more pronounced by increasing furfural concentration and exposure time (especially at 2h exposure). After 12 h, no viable J2 were detected at high concentrations (1.5%).