Hamasat Abd Elhafeez Abd Elkhalek Abd Elkader Elnoury
Asst. Professor
CO‑RADS score and its correlation with clinical and laboratory parameters in patients with COVID‑19
• 2024
Publication Information
Authors
Marwa Elsayed Elnaggar1* , Abeer Mohamed Rawy1, Marwa Seif El‑Melouk2, Al‑Shaimaa Mahmoud Al‑Tabbakh2,
Hamasat Abdel‑hafeez Abdel‑Khalik3, Eman Fathy Abdelkhalek4 and Rehab Elsayed Elsawy1
Keywords
Not Available
Journal
Not Available
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Background Polymerase chain reaction (PCR) based SARS-CoV-2 RNA detection and serological antibody tests give
a proof of Coronavirus Disease 2019 (COVID-19) infection. Several variables can influence the consequences of these
tests. Inflammatory markers among mild and severe patients of COVID-19 showed dissimilarity in inflammatory markers
while computed tomography (CT) in patients infected with COVID-19 used to evaluate infection severity. The aim
of this study is to investigate the application of the COVID-19 Reporting and Data System (CO-RADS) classification in
COVID-19 patients and its relation to clinical and laboratory finding.
Results One hundred patients suspected to have COVID-19 infection were involved. Their age was 49.6 ± 14.7. Fever
and cough were the frequent presenting symptoms. Patients with positive PCR were significantly associated with
dyspnea and higher inflammatory markers. Lymphopenia had sensitivity of 63.6% and specificity of 91.7%. Combination
of PCR and lymphopenia increased both sensitivity and specificity. CT findings in relation to PCR showed sensitivity
of 90.5% and specificity of 25%. CO-RADS score showed positive correlation with age and inflammatory biomarkers
and negative correlation with absolute lymphocyte count (ALC).
Conclusions CT finding was more prominent in older patients with COVID-19 and associated with higher inflammatory
biomarkers and lower ALC which were correlated with CO-RADS score. Patients with positive PCR had more
symptoms and inflammatory marker. Combination of PCR with either lymphopenia or CT finding had more sensitivity,
specificity and accuracy in diagnosis
a proof of Coronavirus Disease 2019 (COVID-19) infection. Several variables can influence the consequences of these
tests. Inflammatory markers among mild and severe patients of COVID-19 showed dissimilarity in inflammatory markers
while computed tomography (CT) in patients infected with COVID-19 used to evaluate infection severity. The aim
of this study is to investigate the application of the COVID-19 Reporting and Data System (CO-RADS) classification in
COVID-19 patients and its relation to clinical and laboratory finding.
Results One hundred patients suspected to have COVID-19 infection were involved. Their age was 49.6 ± 14.7. Fever
and cough were the frequent presenting symptoms. Patients with positive PCR were significantly associated with
dyspnea and higher inflammatory markers. Lymphopenia had sensitivity of 63.6% and specificity of 91.7%. Combination
of PCR and lymphopenia increased both sensitivity and specificity. CT findings in relation to PCR showed sensitivity
of 90.5% and specificity of 25%. CO-RADS score showed positive correlation with age and inflammatory biomarkers
and negative correlation with absolute lymphocyte count (ALC).
Conclusions CT finding was more prominent in older patients with COVID-19 and associated with higher inflammatory
biomarkers and lower ALC which were correlated with CO-RADS score. Patients with positive PCR had more
symptoms and inflammatory marker. Combination of PCR with either lymphopenia or CT finding had more sensitivity,
specificity and accuracy in diagnosis