Heba Elsayed Abd Elhaliam Baioumy
Lecturer
Mito-TEMPO, A Selective Mitochondrial Antioxidant Alleviates Acrylamide-Mediated Anterior 2/3 Lingual Damage in Rats. Biochemical, Histological and Immunohistochemical Study
• 2023
Publication Information
Authors
Heba Bayoumi1, Enas Elgendy1, Hala Taha Shalan2, Ebtssam Beder3, Nashwa Elsayed4
and Amira Elalfy1
Keywords
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Pages
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publication.type
International
Paper Link
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Abstract
Background: Acrylamide (ACR) is a common toxicant. One of the most critical worldwide health issues right now is the
exposure of individuals and animals to ACR through their diet. Dietary antioxidants have received attention as potential
preventive strategy and as a nutritional supplement for addressing various ACR-induced toxicities.
Aim of work: Studying the potential protective effect of Mito-TEMPO (MT) a selective mitochondrial antioxidant on
acrylamide induced lingual toxicity.
Study design: Thirty two adult male rats were separated into 3 sets. Group I (control group). Group II (ACR group): Rats
were treated with 40 mg/kg/d acrylamide that was dissolved in physiological saline and given orally by gavage for 14 days.
Group III (ACR+ MT group): Rats were treated as group II and were injected with 0.7 mg/kg of Mito-TEMPO (ip) once/day
for 2 days before acrylamide and continued with acrylamide for another 14 days. It was given 30 minutes before acrylamide.
Results: Acrylamide intoxicated group revealed significant decline (P
exposure of individuals and animals to ACR through their diet. Dietary antioxidants have received attention as potential
preventive strategy and as a nutritional supplement for addressing various ACR-induced toxicities.
Aim of work: Studying the potential protective effect of Mito-TEMPO (MT) a selective mitochondrial antioxidant on
acrylamide induced lingual toxicity.
Study design: Thirty two adult male rats were separated into 3 sets. Group I (control group). Group II (ACR group): Rats
were treated with 40 mg/kg/d acrylamide that was dissolved in physiological saline and given orally by gavage for 14 days.
Group III (ACR+ MT group): Rats were treated as group II and were injected with 0.7 mg/kg of Mito-TEMPO (ip) once/day
for 2 days before acrylamide and continued with acrylamide for another 14 days. It was given 30 minutes before acrylamide.
Results: Acrylamide intoxicated group revealed significant decline (P