Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that affects 6% to 10% of women of reproductive age.. Aim of the research was to examine the effect of self instructional module on awareness of polycystic ovarian syndrome among adolescent students. Design: A quasi-experimental research design was adopted to fulfil the aim of this study. Setting: The study was conducted at nursing institute of Benha teaching hospital and nursing institute of health insurance hospital. Sample:A purposive sample of one hundred and seventy five adolescent girls among those attending the above mentioned setting. Tools: Data were collected through four main tools: A Structured interviewing questionnaire, knowledge questionnaire regarding polycystic ovarian syndrome, adaptive healthy measures questionnaire regarding PCOS and adolescent student’s satisfaction sheet. Results: showed that the majority of adolescent students (89.7) had no information about PCOS while minority of them had source of information from health team , mass media ,family and friends respectively. and only 6.3 %of adolescent girls had adequate knowledge pre implementation increased to 90.3 % post implementation. Also there was a highly statistically significant difference between total knowledge and total adaptive healthy measures score related to PCOS at the pre and post implementation phases (p