Hend El Sayed Nasr El sayed
Asst. Professor
Hibiscus attenuates renovascular hypertension–induced aortic remodeling dose dependently: the oxidative stress role and Ang II/ cyclophilin A/ERK1/2 signaling
• 2023
Publication Information
Authors
Asmaa Mohammed ShamsEldeen1*, Ahmed Fawzy1,
Hend Ashour1,2*, Marwa Abdel-Rahman1, Hend Elsayed Nasr3,
Lina Abdelhady Mohammed3, Noha Samir Abdel Latif4,
Amr M. Mahrous5 and Shereen Abdelfattah6
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publication.type
Local
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Abstract
Introduction: The high levels of angiotensin II (Ang II) can modify the vascular
tone, enhance vascular smooth muscle cells (VSMCs) proliferation and
hypertrophy and increase the inflammatory cellular infiltration into the vessel
wall. The old herbal nonpharmacological agent, Hibiscus (HS) sabdariffa L has
multiple cardioprotective impacts; thus, we investigated the role of HS extract in
amelioration of renovascular hypertension (RVH)-induced aortic remodeling.
Materials and methods: Thirty-five rats (7/group) were randomly allocated into 5
groups; group: I: Control-sham group, and RVH groups; II, III, IV, and V. The rats in
RVH groups were subjected to the modified Goldblatt two-kidneys, one clip
(2K1C) for induction of hypertension. In group: II, the rats were left untreated
whereas in group III, IV, and V: RVH-rats were treated for 6 weeks with low dose
hibiscus (LDH), medium dose hibiscus (MDH), and high dose hibiscus (HDH)
respectively
tone, enhance vascular smooth muscle cells (VSMCs) proliferation and
hypertrophy and increase the inflammatory cellular infiltration into the vessel
wall. The old herbal nonpharmacological agent, Hibiscus (HS) sabdariffa L has
multiple cardioprotective impacts; thus, we investigated the role of HS extract in
amelioration of renovascular hypertension (RVH)-induced aortic remodeling.
Materials and methods: Thirty-five rats (7/group) were randomly allocated into 5
groups; group: I: Control-sham group, and RVH groups; II, III, IV, and V. The rats in
RVH groups were subjected to the modified Goldblatt two-kidneys, one clip
(2K1C) for induction of hypertension. In group: II, the rats were left untreated
whereas in group III, IV, and V: RVH-rats were treated for 6 weeks with low dose
hibiscus (LDH), medium dose hibiscus (MDH), and high dose hibiscus (HDH)
respectively