Marwa Mohamed Mourad Fawzy Abd Elrahman
Lecturer
Comparative Efficacy of Coriander Seed Extract-Loaded Selenium Nanoparticles and DMSA in Restoring Antioxidant/Apoptotic Balance of Lead-Induced Hepatotoxicity
• 2026
Publication Information
Authors
Eslam Elshaier1 · Abdel Ghany F. Shoair2 · Rehab Reda Hassan1 · Mansour Emad1 · Noureen ELKattan1 ·
Ahmed Khalifa1 · Mohamed Essam1 · M. M. Farag3 · Fayez Althobaiti4 · Marwa M. M. Fawzy5 · Heba A. Sahyon1
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publication.type
Local
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Abstract
Lead (Pb) is a heavy metal that causes hepatotoxicity even in trace amounts. This study investigated the therapeutic
potential of coriander extract-loaded selenium nanoparticles (coriander@Se-NPs) against Pb toxicity in a mouse model,
comparing its efficacy to the benchmark standard chelator, DMSA. The effectiveness of coriander extract, coriander@Se-
NPs, and synthetic chelator (DMSA) was evaluated. The study groups contain: a control group receiving distilled water, a
Pb toxicity group given Pb-acetate at 150 mg/kg, a positive control group treated with DMSA after Pb exposure, and two
groups receiving coriander extract or coriander@Se-NPs after Pb exposure, both at 200 mg/kg daily for three weeks. Our
results demonstrated that the coriander@Se-NPs significantly reduced hepatic Pb concentrations (83.90%) and restored
antioxidant enzyme activities (SOD and CAT) more effectively than DMSA. Notably, coriander@Se-NPs exhibited potent
anti-inflammatory and anti-apoptotic effects, evidenced by a 12.5-fold reduction in IL-6 and the suppression of Caspase 3
to sub-normal levels (0.399-fold). Furthermore, the coriander@Se-NPs treatment stabilized Beclin 1 levels, suggesting a
restoration of cellular autophagy homeostasis. These findings indicate that coriander@Se-NPs provide a superior, multimodal
protective shield against heavy metal poisoning compared to traditional synthetic chelators, DMSA, highlighting
their potential as a high-efficacy nanomedicine for clinical toxicology. Further studies are needed to explore its potential
clinical applications and mechanisms.
potential of coriander extract-loaded selenium nanoparticles (coriander@Se-NPs) against Pb toxicity in a mouse model,
comparing its efficacy to the benchmark standard chelator, DMSA. The effectiveness of coriander extract, coriander@Se-
NPs, and synthetic chelator (DMSA) was evaluated. The study groups contain: a control group receiving distilled water, a
Pb toxicity group given Pb-acetate at 150 mg/kg, a positive control group treated with DMSA after Pb exposure, and two
groups receiving coriander extract or coriander@Se-NPs after Pb exposure, both at 200 mg/kg daily for three weeks. Our
results demonstrated that the coriander@Se-NPs significantly reduced hepatic Pb concentrations (83.90%) and restored
antioxidant enzyme activities (SOD and CAT) more effectively than DMSA. Notably, coriander@Se-NPs exhibited potent
anti-inflammatory and anti-apoptotic effects, evidenced by a 12.5-fold reduction in IL-6 and the suppression of Caspase 3
to sub-normal levels (0.399-fold). Furthermore, the coriander@Se-NPs treatment stabilized Beclin 1 levels, suggesting a
restoration of cellular autophagy homeostasis. These findings indicate that coriander@Se-NPs provide a superior, multimodal
protective shield against heavy metal poisoning compared to traditional synthetic chelators, DMSA, highlighting
their potential as a high-efficacy nanomedicine for clinical toxicology. Further studies are needed to explore its potential
clinical applications and mechanisms.