Mohamed Abd El-Rahman Mousa Abo-Riya
Vice Dean
Synthesis and Anticancer Activity Evaluation of Some Thienopyrimidine Derivatives
• 2021
Publication Information
Authors
21- M. A. Mohamed, R. R. Khattab, A. A. F. Wasfy, M. A. Abo-Riya, S. El-Kalyoubi, and N. A. Hassan
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publication.type
International
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Abstract
The current study focused on effective and straightforward routes for preparing a new series of
thieno[2,3-d]pyrimidine derivatives in addition to their acyclo nucleosides analogue. The chemical structures
of the synthesized products have been elucidated through diverse spectroscopy analyses such as (IR, NMR,
MS, and elemental analyses). Some selected thienopyrimidine derivatives were investigated for their anticancer activity against two human cancer cell lines (HepG-2 and MCF-7). The results revealed that compounds
3-ethyl-2-hydrazineyl-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-oneand3-ethyl-2-
(2-glucozylidenehydrazineyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one showed the
most potent anticancer activity
thieno[2,3-d]pyrimidine derivatives in addition to their acyclo nucleosides analogue. The chemical structures
of the synthesized products have been elucidated through diverse spectroscopy analyses such as (IR, NMR,
MS, and elemental analyses). Some selected thienopyrimidine derivatives were investigated for their anticancer activity against two human cancer cell lines (HepG-2 and MCF-7). The results revealed that compounds
3-ethyl-2-hydrazineyl-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-oneand3-ethyl-2-
(2-glucozylidenehydrazineyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one showed the
most potent anticancer activity