Morphological changes are important in preserving the Nile River due to the construction of hydraulic structures such as dams and barrages. The Delft-3D model was employed to evaluate, analyze, and predict morphological changes as a result of the construction of the New Assiut Barrage, which is located at the fourth reach of the Nile River. The bathymetric and topographic data, water levels, discharges, velocities, and bed levels were gathered from the Nile Research Institute for the study area in 2006, 2008, 2015, and 2017. The morphological changes were evaluated and analyzed in the period from 2015 to 2025. Results obtained indicate morphological changes around the Bani Mur and EL-Walidia Islands. There was sedimentation and erosion on both the eastern and western sides of Bani Mur Island, with sedimentation being more pronounced on the eastern side. So, dredging must be done continuously to avoid affecting the navigational path, where there are two navigational locks at the east of the Bani Mur Island. Also, erosion occurred on the left side of EL-Walidia Island.