Mona Kamal El-Awam
Asst. Professor
An emerging role of Beclin-1-mediated autophagy in the cardioprotective impact of Lactobacillus acidophilus in diabetic hyperlipidemic rats beside the antioxidant and antiinflammatory potency
• 2025
Publication Information
Authors
Walaa H.Mohammed1
, Mona K. Alawam1
, Israa H. Khairat2
,Sania K. Elwia3
, Marwa Said
El-sayed4
, Mahmoud M. Hassan1
, Marwa H. Muhammad1*
Keywords
Not Available
Journal
Not Available
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Background: Cardiac dyshomeostasis is steadily increasing in obese diabetics, with growing
evidence pointing to a potential connection between diabetic cardiomyopathy (DCM) and gut
microbiota alterations. The probiotic Lactobacillus acidophilus (Lacto-B) has garnered significant
interest for its beneficial properties. This study aimed to explore the mechanisms by which LactoB exerts its protective effects and to assess the role of beclin-1-mediated autophagy in DCM.
Method: Twenty-four rats were grouped into Control, Lacto-B, high-fat diet (HFD), and HFD +
Lacto-B, for 8-week experimental period. Lacto-B was administrated at a dose of (2 x 108
)
colony-forming units/ml/d by oral gavage. Echocardiographic, biochemical, and microscopic
evaluations for cardiac changes were assessed. Glycemic and lipid profiles, oxidative stress,
inflammatory markers nuclear factor-кB, interleukin-1β, interleukin-10, and beclin-1 protein were
evaluated
evidence pointing to a potential connection between diabetic cardiomyopathy (DCM) and gut
microbiota alterations. The probiotic Lactobacillus acidophilus (Lacto-B) has garnered significant
interest for its beneficial properties. This study aimed to explore the mechanisms by which LactoB exerts its protective effects and to assess the role of beclin-1-mediated autophagy in DCM.
Method: Twenty-four rats were grouped into Control, Lacto-B, high-fat diet (HFD), and HFD +
Lacto-B, for 8-week experimental period. Lacto-B was administrated at a dose of (2 x 108
)
colony-forming units/ml/d by oral gavage. Echocardiographic, biochemical, and microscopic
evaluations for cardiac changes were assessed. Glycemic and lipid profiles, oxidative stress,
inflammatory markers nuclear factor-кB, interleukin-1β, interleukin-10, and beclin-1 protein were
evaluated