Nashwa Farouk Mohammed El-Metwaly
Lecturer
Value of Neutrophil Gelatinase-Associated Lipocalin in Diagnosis of Renal Disorders in Children with Glycogen Storage Disease Value of Neutrophil Gelatinase-Associated Lipocalin in Diagnosis of Renal Disorders in Children with Glycogen Storage Disease
Alexandria journal of pediatrics • 2024
Publication Information
Authors
Nashwa.F. Mohamed1, Ola G Behairy1, Effat Hussein Assar1, Hend Talal Fayek1, Dina Saad Abdelmotaleb 2
Keywords
Not Available
Journal
Alexandria journal of pediatrics
Publisher
Not Available
Volume
37
Issue
No 3
Pages
212-218
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Purpose: This study aimed to evaluate the value of urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) in diagnosis of renal disorders in children with Glycogen Storage Disease (GSD).
Methods: This cross-sectional study, was conducted at Benha University Hospital, Egypt, included 50 children with GSD and apparently healthy 50 children as a control group. The level of NGAL were measured in urine by ELISA, and compared between groups.
Results: GSD group had statistically significant higher urinary NGAL (147.6±38.8 ng/ml) compared to control group (102.1±11.4 ng/ml), p2), patients with higher degree of liver fibrosis. At a cutoff point > 154 ng/ml, urinary NGAL could detect cases with microalbuminuria with sensitivity 83.3% and specificity 94.7%, At a cutoff point > 172 ng/ml, urinary NGAL could detect cases with acute Kidney injury (RIFLE >2); with sensitivity 100% and specificity 100%.
Conclusion: Urine NGAL demonstrates superior efficacy as a biomarker for the precocious identification of renal dysfunction in pediatric patients afflicted with glycogen storage diseases.
Keywords: NGAL; Renal Disorders; Children; Glycogen Storage Diseases
Methods: This cross-sectional study, was conducted at Benha University Hospital, Egypt, included 50 children with GSD and apparently healthy 50 children as a control group. The level of NGAL were measured in urine by ELISA, and compared between groups.
Results: GSD group had statistically significant higher urinary NGAL (147.6±38.8 ng/ml) compared to control group (102.1±11.4 ng/ml), p2), patients with higher degree of liver fibrosis. At a cutoff point > 154 ng/ml, urinary NGAL could detect cases with microalbuminuria with sensitivity 83.3% and specificity 94.7%, At a cutoff point > 172 ng/ml, urinary NGAL could detect cases with acute Kidney injury (RIFLE >2); with sensitivity 100% and specificity 100%.
Conclusion: Urine NGAL demonstrates superior efficacy as a biomarker for the precocious identification of renal dysfunction in pediatric patients afflicted with glycogen storage diseases.
Keywords: NGAL; Renal Disorders; Children; Glycogen Storage Diseases