Omnia Youssef
Professor
Expression of PD-1/PD-L1 and P53 in hepatocellular carcinomarelationship with clinicopathological parameters
Egyptian Journal of Pathology • 2018
Publication Information
Authors
Bassyoni, Omneya Y.; Rashad, Heba M.
Keywords
Not Available
Journal
Egyptian Journal of Pathology
Publisher
LWW
Volume
38
Issue
1
Pages
131-138
publication.type
Local
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Previously described immune checkpoint regulators, programmed cell death (PD-1) and its main ligand (PD-L1) are known to regulate T-cell function and control proliferation of tumor cells. A connection between P53 and those checkpoint has been reported in cancer cells. This work aimed at studying the expression for PD-1/PD-L1 and P53 protein in hepatocellular carcinoma (HCC) and correlate them with clinicopathological parameters.
Materials and methods
Immunohistochemical expression of PD-1/PD-L1 and P53 was evaluated in 33 cases of HCC and eight cases of non-neoplastic liver samples (hepatitis) were used as control.
Results
PD-1/PD-L1 and P53 showed higher expression in HCC cases compared to non-neoplastic liver tissue (P
Materials and methods
Immunohistochemical expression of PD-1/PD-L1 and P53 was evaluated in 33 cases of HCC and eight cases of non-neoplastic liver samples (hepatitis) were used as control.
Results
PD-1/PD-L1 and P53 showed higher expression in HCC cases compared to non-neoplastic liver tissue (P