Rasha Mahmoud Abdrabh Mahmoud
Asst. Professor
Significance of epithelial cell adhesion molecule and epidermal growth factor receptor expression in papillary thyroid carcinoma: an immunohistochemical study
• 2019
Publication Information
Authors
Rasha M. Abdrabh, Heba M. Rashad
Keywords
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publication.type
International
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Abstract
Thyroid carcinoma ranks as the most common among malignancies of endocrine AQ5
organs, and a rapid increase in its incidence has been observed over the years.
Assessment of epithelial cell adhesion molecule (EpCAM) and epidermal growth
factor receptor (EGFR) immunopositivity in papillary carcinoma thyroid was
conducted, and expression was correlated with the clinicopathological parameters.
Materials and methods
Immunohistochemical detection of EpCAM and EGFR was investigated in 33
thyroidectomy specimens with papillary carcinoma and 10 cases of hyperplastic
thyroid nodule. The association between those markers was studied, besides their
correlation with clinicopathological parameters.
Results
Both EpCAM and EGFR showed weak or low expression in hyperplastic nodule
compared with higher expression in papillary carcinoma (P
organs, and a rapid increase in its incidence has been observed over the years.
Assessment of epithelial cell adhesion molecule (EpCAM) and epidermal growth
factor receptor (EGFR) immunopositivity in papillary carcinoma thyroid was
conducted, and expression was correlated with the clinicopathological parameters.
Materials and methods
Immunohistochemical detection of EpCAM and EGFR was investigated in 33
thyroidectomy specimens with papillary carcinoma and 10 cases of hyperplastic
thyroid nodule. The association between those markers was studied, besides their
correlation with clinicopathological parameters.
Results
Both EpCAM and EGFR showed weak or low expression in hyperplastic nodule
compared with higher expression in papillary carcinoma (P