Context: Effective post cardiac arrest care results from successful resuscitation that can evolveinthedays to weeks following the return of sustained circulation. So, electronic learning has growntremendously and is now integrated into nursing education. Aim: Evaluate the effect of electroniclearning package application on nurses’ knowledge and practice regarding post cardio pulmonaryresuscitation for critically ill neonates. Methods: The current study was conducted usingaquasi-experimental design. Setting: This study was conducted at NICUs at Benha University Hospital inBenha city. Sampling: A convenient sample of 70 nurses from the previously mentioned settingswasincluded in the current study regardless of their personal characteristics. Study tools: There weretwotools used, Tool I: a structured interviewing questionnaire. Tool II: An observational checklist toassessnurses' practice regarding post cardio pulmonary resuscitation for critically ill neonates. Results:There was a positive correlation between total nurses' knowledge and practice scores post electroniclearning package application. Conclusion: It can be concluded that, electronic learningpackageapplication had a positive effect on nurses' knowledge and practice level, which indicates that, theelectronic learning package application is greatly effective. Recommendation: Thestudyrecommended that, an updated electronic learning and training programs should be periodicallycarriedout with numerous teaching methods for nurses in NICUs for improving their performance regardingpost cardio pulmonary resuscitation.