Background: Depression is among the most prevalent psychological disorders, significantlyimpacting an individual's performance and resulting in numerous adverse consequences. Thethirdphase of psychotherapy aimed at treating mental health issues, especially depression, is knownascompassion-focused therapy (CFT).The aim of this intervention is to better manage the patient’sdysfunctional attitude and automatic thoughts and enhance depressive symptoms .Aim: Toevaluatethe efficacy of psychological interventions based on compassion-focused therapy on automaticthoughts and dysfunctional attitudes among patients with depressive symptoms. Setting: Theresearch was conducted at the psychiatric inpatient ward of the Hospital of Mental HealthandAddiction Treatment located in Benha City, Qaluobia. Subjects: A purposive sample of seventypatients with depressive symptoms was selected as study group (35 patients) and the control group(35 patients). Research Design: Quasi-experimental research design pre- post,and follow-uptest, two groups were utilized. Tools: Four tools were used; Tool (1) Socio-demographic dataandclinical characteristics, Tool (2) Self Compassion Scale, Tool (3) the Automatic ThoughtsQuestionnaire (ATQ) and Tool (4) Dysfunctional Attitude Scale (DAS). Results: There wasastatistically significant positive correlation coefficient between the total number of automaticthoughts and dysfunctional attitudes among patients with depressive symptoms in the studygroup, and compassion-based therapy significantly reduced these thoughts and attitudes in patients withdepressive symptoms (p