remah sobhy atia abd elrazek
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Flavan-3-ol, a tabulated flavanol from date seeds, de-glycated proteins by trapping its glycoxidation sites, di-carbonyls, and OH-radicals in BSA-Fenton liquid models
• 2024
Publication Information
Authors
Remah Sobhy, Jianing Zhang, Zhihua Li, Xiaobo Zou, Asad Nawaz, Noman Walayat, Salim Manoharadas, Yangyang Jia, Mahmoud Salah
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publication.type
International
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Supplementary Materials
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Abstract
We aimed at tabulating and characterizing a flavan-3-ol isolated from date seeds into date seed pills (DSP) as a commercial healthcare pill, and deeply studying their anti-glycoxidation impacts on bovine serum albumin using multi-dimensional approaches SDS-PAGE/NBT, UPLC-ESI-Q-TOF-MS, antiradical via Fenton-type reaction, multispectral, and molecular docking. Results showed that DSP were successfully tabulated (an encapsulation efficiency of 98.78 %) with high antioxidant values via noncovalently binding with whey proteins supported by FTIR and lib-dock results. DSP dose-dependently decayed fluorescent-AGEs by 16.77, 5.32, and 37.41 % in DSP500-BSA-G/MGO/GO models, respectively, later confirmed by SDS-PAGE and initial precursors mitigation results. The docking results confirmed that DSP could bind with glycoxidation sites of BSA-subunits, namely Lys431, Arg458, and Arg196 via H-bonds …