Background: Hyperglycemia is a chronic illness that is associated with
diabetes. Patients with diabetes have been found to have many alterations in their
renal functioning. The aim of this study was to evaluate the potential benefits of
diosmin and ginger, either separately or in combination, for diabetic nephropathy that
was experimentally produced.
Materials and Methods: Group I, ten rats stood as a control group. All rats
(except control group) were given a single intraperitoneal dose of alloxan (150 mg/kg
body weight) to induce type 2 diabetes. Group II consisted of ten diabetic rats. Other
ten diabetic rats received 100 mg/kg diosmin orally for six weeks as part of Group III.
Also other ten diabetic rats; part of Group IV received 400 mg/kg of ginger orally for
six weeks. The last ten diabetic rats in Group V received oral treatment for six weeks
with ginger (400 mg/kg) and diosmin (100 mg/kg). Rats were sacrificed after the six
weeks, and kidney tissue and blood samples were taken for several biochemical
analyses. Both an ultrastructural investigation and hemotoxylin and eosin staining
were performed. The desmin and Nrf2 immunohistochemical markers were used.
There were statistical and morphometric studies performed