Benha University

Shuzan Ali Mohammed Ali

Professor

Faculty of Medicine Biochemistry

Role of miR-7 as Potential Biomarker for Colorectal Cancer

Benha Journal of Applied Sciences (BJAS) • 2024
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Publication Information
Authors Nourhan M.Attia, Amal A.Hassan, Shuzan A.Mohammed, Emad M.Sarhan and Lina A.Mohamed
Keywords Colorectal cancer and microRNA-7.
Journal Benha Journal of Applied Sciences (BJAS)
Publisher Benha University
Volume 9
Issue 11
Pages 73 - 77
publication.type Local
Paper Link Open Link
Supplementary Materials Not Available
Abstract
Two-thirds of colorectal cancers (CRCs) occur in more developed parts of the world, making it the third most frequent
cancer globally after lung and breast cancers. All racial and ethnic groups are affected by CRC, which primarily affects
those 50 years of age and older. This condition may arise as a result of a variety of circumstances, including environmental
and hereditary ones. The majority of cases are discovered until after symptoms appear, despite the fact that colorectal
cancer screening lowers the frequency of diagnosis at advanced stages. MicroRNAs (miRNA), which are frequently
dysregulated in cancer, are crucial for regulating gene expression. Since miR-7 affects the expression of several oncogenes,
revealing how miR-7 activity is regulated will probably help us better understand the causes of different types of cancer.
The purpose of this study was to look at how miR-7 affects colorectal cancer. We discovered a strong correlation between
CRC and miR-7.
miRNA-7 is circulating as a possible non-invasive biomarker for several illnesses and disorders, including colorectal
cancer. This study sought to determine whether microRNA-7 may be used as a diagnostic tool for colorectal cancer
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