Background: The surgical treatment for osteoarthritis in its advanced stages is knee
replacement surgery, which is helpful in reducing pain, correcting deformities, and restoring
function. In order to improve patient outcomes and their rate of recovery, evidence-based nursing
recommendations are essential. Aim: Was to evaluate the effect of evidence-based nursing
guidelines on patients' quality of life after knee replacement surgery. Research design: This
research's aim was achieved through the use of a quasi-experimental research design specifically a
one-group pre/post-test. Setting: The research was carried out at Benha University Hospital in the
Qualyubia Governorate, Egypt, at the orthopedic department, which is connected to the surgery
department and outpatient clinics. Subjects: The research included a convenience sample of 100
patients who underwent knee replacement surgery. Instruments: Two tools were used: Tool (I): A
structured interviewing questionnaire, it involved the patients' personal data, medical history and
patients' knowledge assessment. The second tool was the patients' Quality of Life Scale, which
included three domains: The social, psychological, and physical. Results: According to the
research's findings, the overall knowledge levels over the several research phases varied in a very
statistically meaningful way. In contrast, 27% of the patients had a satisfactory level of overall
knowledge about knee replacement surgery prior to the adoption of the guidelines, and 88%, 85%,
and 82% of them had a satisfactory level of knowledge immediately following, three months after,
and six months after the guidelines were implemented and the patients' overall mean quality of life
score was 51.38 ± 3.83 prior to the nursing guidelines implementation, and it changed to 47.27 ±
4.27 and 31.92 ± 4.89 post three and six months of the guidelines' implementation, with highly
significant differences (p=