Zeinab Ibrahim Helmy Elshawarby
Asst. Professor
Prognostic Significance of Renin and Erythropoietin (Proteins Related to Renin Angiotensin system Pathway) Expression in Clear Cell Renal Cell Carcinoma (Immunohistochemical Study)
• 2025
Publication Information
Authors
Zeinab I. Elshawarby*1, Eman A. Saad1, Hiam A. Eleleimy2, Kareem Ali El Attar3, Hanan Ahmed1
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publication.type
Local
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Abstract
Background: Clear cell renal cell carcinoma (ccRCC) is considered the most common histopathological subtype and constituting nearly 70% of all primary renal cell carcinomas. Dysregulation of proteins related to Renin-Angiotensin System (RAS) could offer a new prognostic indicator in this malignant neoplasm.
Objective: This study aimed to demonstrate renin (REN) & erythropoietin (EPO) immunohistochemical expression in ccRCC cases & their expression was correlated with the clinicopathological data & survival of the studied cases to explore their potential prognostic role.
Material and methods: This retrospective research carried upon 30 cases ccRCC immunohistochemically stained with REN and EPO & the results to be correlated with different clinicopathological variables and patient's survival.
Objective: This study aimed to demonstrate renin (REN) & erythropoietin (EPO) immunohistochemical expression in ccRCC cases & their expression was correlated with the clinicopathological data & survival of the studied cases to explore their potential prognostic role.
Material and methods: This retrospective research carried upon 30 cases ccRCC immunohistochemically stained with REN and EPO & the results to be correlated with different clinicopathological variables and patient's survival.