The main aim of this study was to enhance the production of oil from sesame seeds by optimizing the extraction screw speed and extraction temperature. To achieve that, the effect of different extraction temperatures (45, 55, and 65 °C) and different extraction screw speeds (75, 90 and 120 rpm) on oil extraction yield, extraction efficiency, extraction energy requirements and extraction time were studied. The results most important indicate that the sesame oil yield increased from 49.6 to 52.4, 49.2 to 52.0 and 48.0 to 51.2 %, when the extraction temperature increased from 45 to 65 ºC, for 75, 90, and 120 rpm screw speeds, Respectively. The highest value of the extraction efficiency (84.52%) was found at 65 °C extraction temperature and 75 rpm screw speed. The lowest value of the extraction time (2.203 min) was found at 65 ℃ extraction temperature and 120 rpm screw speed. The optimal specific energy consumption was 0.215 kW.h/kgoil was obtained at 65 °C extraction temperature and 120 rpm screw speed.